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Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站

A |     8月15日晚，26092期大乐透开奖，全国开出4注一等奖，其中一注基本一等奖花落大连市普兰店区皮口镇的第02365号实体店。    

    Photo: VCG
Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday. 
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels. 
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions. 
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts. 
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times. 
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。8月16日，大奖实体店内外喜气洋洋。据大奖实体店代销者段女士介绍，这是站里第一次中出体彩大奖，中奖者是站里的一位老顾客，15日晚买了5注号码，一共花了10元钱，能喜提960万元一等奖，“太幸运了，真为他高兴！”段女士经营彩票站20多年，与许多购彩者都处成了朋友。

B | 16日一早，她还接到中奖者的电话，“我中奖了，中大奖了，谢谢彩票站！”有意思的是，由于中奖者不怎么会上网，所以当时并不知道奖金具体是多少，还以为是500万元，当得知奖金有960万元时，他惊讶到不敢相信，“真的吗？没想到有这么多！”为此，中奖者特意赶到体彩实体店，亲眼看到机器上显示的系统提示和开奖结果，才确信无疑。

C | 截至目前，大连购彩者今年已经中得5注大乐透大奖，前4注分别是在3月16日、4月6日、4月18日和7月8日中出的，总奖金达到4600余万元。

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Published on:19:53:44